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Comparative Study
. 1992 Jul;83(7):676-9.
doi: 10.1111/j.1349-7006.1992.tb01964.x.

Elevated levels of plasma transforming growth factor-beta in patients with hepatocellular carcinoma

Y Shirai  1 , S Kawata, N Ito, S Tamura, K Takaishi, S Kiso, H Tsushima, Y Matsuzawa
Affiliations
Comparative Study

Elevated levels of plasma transforming growth factor-beta in patients with hepatocellular carcinoma

Y Shirai et al. Jpn J Cancer Res. 1992 Jul.

Abstract

We measured the plasma transforming growth factor-beta (TGF-beta) concentration in 14 patients with human hepatocellular carcinoma (HCC) and 9 age-matched normal subjects using growth inhibition assay of mink lung epithelial cells. The calculated plasma TGF-beta concentration in the patients with HCC was 28.6 +/- 27.9 ng/ml (mean +/- SE), showing significant elevation compared with that in 9 normal subjects (5.3 +/- 3.3 ng/ml, P less than 0.01). In three cases, we could measure plasma TGF-beta levels before and after their treatment for HCC. The plasma TGF-beta levels decreased from 59.0 to 18.2 ng/ml after hepatic resection in one case, and from 24.0 to 10.7 ng/ml and from 12.4 to 3.4 ng/ml after transhepatic arterial embolization in the other two cases. These data indicate that plasma TGF-beta level is elevated in patients with HCC, probably due to release from HCC tissues.

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