Properties of the guinea-pig lung platelet-activating factor receptor encoded by the cloned cDNA
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- PMID: 1326344
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Properties of the guinea-pig lung platelet-activating factor receptor encoded by the cloned cDNA
J Lipid Mediat.
1992 Jun-Jul.
Abstract
Platelet-activating factor (PAF) is a naturally occurring phospholipid possessing proinflammatory and shock-inducing activities. Although PAF exerts these functions via specific receptors, the molecular structures of the receptor has not been clarified. We have isolated a cDNA coding for PAF receptor through expression cloning. The PAF receptor expressed in Xenopus laevis oocytes and COS-7 cells showed pharmacological properties consistent with those in previous reports. Sequence analysis revealed that PAF receptor belongs to the superfamily of G-protein-coupled receptors.
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