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. 1992 Jun-Jul;5(2):105-7.

Properties of the guinea-pig lung platelet-activating factor receptor encoded by the cloned cDNA

Z Honda  1 , M Nakamura, Y Seyama, T Shimizu
Affiliations
  • PMID: 1326344

Properties of the guinea-pig lung platelet-activating factor receptor encoded by the cloned cDNA

Z Honda et al. J Lipid Mediat. 1992 Jun-Jul.

Abstract

Platelet-activating factor (PAF) is a naturally occurring phospholipid possessing proinflammatory and shock-inducing activities. Although PAF exerts these functions via specific receptors, the molecular structures of the receptor has not been clarified. We have isolated a cDNA coding for PAF receptor through expression cloning. The PAF receptor expressed in Xenopus laevis oocytes and COS-7 cells showed pharmacological properties consistent with those in previous reports. Sequence analysis revealed that PAF receptor belongs to the superfamily of G-protein-coupled receptors.

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