Hetrazepine PAF antagonists
Affiliations
- PMID: 1326346
Item in Clipboard
Hetrazepine PAF antagonists
J Lipid Mediat.
1992 Jun-Jul.
Abstract
Hetrazepines such as WEB-2086 or WEB-2170 are potent, specific, competitive PAF antagonists binding at the same site as the PAF molecule. Despite their structural similarity to known hypnotic drugs they lack hypnotic actions. They almost certainly bind not only cell-surface but also intracellular PAF receptors, which may explain their activity in disease models in which adherence of neutrophils or other cell types to the vascular endothelium plays a role.
Similar articles
-
[Platelet-activating factor (PAF) antagonists].Tanpakushitsu Kakusan Koso. 1991 Feb;36(3):379-87. Tanpakushitsu Kakusan Koso. 1991. PMID: 1850862 Japanese. No abstract available.
-
The platelet activating factor receptor antagonist, RP 59227, blocks platelet activating factor receptors mediating liberation of reactive oxygen species in guinea pig macrophages and human polymorphonuclear leukocytes.J Pharmacol Exp Ther. 1991 Aug;258(2):567-75. J Pharmacol Exp Ther. 1991. PMID: 1650834
-
Pharmacological characterization of a receptor for platelet-activating factor on guinea pig peritoneal macrophages using [3H]apafant, a selective and competitive platelet-activating factor antagonist: evidence that the noncompetitive behavior of apafant in functional studies relates to slow kinetics of dissociation.Mol Pharmacol. 1993 Feb;43(2):302-12. Mol Pharmacol. 1993. PMID: 8381515
-
Regulation of platelet-activating factor (PAF) synthesis and PAF-mediated neutrophil adhesion to endothelial cells activated by thrombin.Semin Thromb Hemost. 1992 Jan;18(1):126-34. doi: 10.1055/s-2007-1002417. Semin Thromb Hemost. 1992. PMID: 1315452 Review. No abstract available.
-
The effects of hetrazepine PAF antagonists in preclinical models of asthma.Agents Actions Suppl. 1991;34:229-45. Agents Actions Suppl. 1991. PMID: 1793067 Review.
Cited by
-
Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.J Clin Invest. 1995 Aug;96(2):940-52. doi: 10.1172/JCI118142. J Clin Invest. 1995. PMID: 7543496 Free PMC article.
-
Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking.J Clin Invest. 1997 May 15;99(10):2358-64. doi: 10.1172/JCI119417. J Clin Invest. 1997. PMID: 9153277 Free PMC article.
-
Effects of UR-12633, a new antagonist of platelet-activating factor, in rodent models of endotoxic shock.Br J Pharmacol. 1996 Jul;118(5):1223-31. doi: 10.1111/j.1476-5381.1996.tb15527.x. Br J Pharmacol. 1996. PMID: 8818347 Free PMC article.
-
Nuclear localization of platelet-activating factor receptor controls retinal neovascularization.Cell Discov. 2016 Jul 12;2:16017. doi: 10.1038/celldisc.2016.17. eCollection 2016. Cell Discov. 2016. PMID: 27462464 Free PMC article.