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. 1992 Oct;66(10):6242-7.
doi: 10.1128/JVI.66.10.6242-6247.1992.

Loss of transformed phenotype upon senescence of Rous sarcoma virus-infected chicken neuroretinal cells

G M Seigel  1 , M F Notter
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Loss of transformed phenotype upon senescence of Rous sarcoma virus-infected chicken neuroretinal cells

G M Seigel et al. J Virol. 1992 Oct.

Abstract

Success in obtaining permanent Rous sarcoma virus-infected chicken cell lines has been limited because of a senescence phenomenon. We show that a diminished, transformed phenotype, followed by dramatic morphological changes, precedes senescence. These changes are associated with continued expression of pp60v-src, as well as specific alterations in expression of two possible phosphorylated substrates of pp60v-src.

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