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. 1992 Jun;38(2):139-54.
doi: 10.1016/0306-9877(92)90087-s.

The dystrophin connection--ATP?

C A Bonsett  1 , A Rudman
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The dystrophin connection--ATP?

C A Bonsett et al. Med Hypotheses. 1992 Jun.

Abstract

Clinical evidence is presented supporting the hypothesis that the metabolic abnormality in the dystrophin-defective muscular dystrophies (DMD and BMD) involves the ATP pathway. Objective laboratory data show corrective trends in the abnormal values of parameters relating to creatine and calcium metabolism (ATP) by use of glucagon-stimulated c-AMP and by use of synthetically produced adenylosuccinic acid (ASA). Disease accelerating mechanisms as suggested by analysis of the clinical features, and the therapeutic potential of ASA are discussed.

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