[Arterial hypertension in children. II. The pathogenetic mechanisms involved in arterial hypertension and the therapeutic correlates]

Abstract

The author discussed the principal pathological mechanisms of the essential hypertension, i.e the importance of sodium and natriuretic factor, the importance of the sympathetic nervous system in the adjustment of the blood pressure, the importance of the renin-angiotensin-aldosterone system, as well as the implication of the kidney by its pressor and depressor mechanisms. The authors emphasized the interrelation of the pressor mechanisms in the essential hypertension. He concluded that the essential hypertension is a "disease of a complex adjustment" with a clinical, biological, haemodynamic and therapeutic heterogeneity, that the genetic factor is well accepted, thus the identification of other genetic markers would have a great importance. There are also presented the principal groups of drugs used in the essential hypertension, in correlation with the pathological mechanisms.