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. 1992 Oct;120(4):569-73.

Combination treatment with ribavirin and interferon for coxsackievirus B3 replication

I Okada  1 , A Matsumori, Y Matoba, M Tominaga, T Yamada, C Kawai
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  • PMID: 1328433

Combination treatment with ribavirin and interferon for coxsackievirus B3 replication

I Okada et al. J Lab Clin Med. 1992 Oct.

Abstract

The effects of combined treatment with ribavirin and recombinant human leukocyte interferon-alpha A/D against Coxsackievirus B3 replication were investigated in cultured cells. Recombinant human leukocyte interferon-alpha A/D was applied 12 hours before Coxsackievirus B3 inoculation and ribavirin was applied 1 hour after Coxsackievirus B3 inoculation on FL (human amnion) cell monolayers. These drugs inhibited Coxsackievirus B3 replication synergistically by plaque-reduction assay. This method of applying drugs may be useful in preventing and treating Coxsackie B virus infection.

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