Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Sep;55(9):844-5.
doi: 10.1136/jnnp.55.9.844.

Botulinum toxin therapy: distant effects on neuromuscular transmission and autonomic nervous system

P Girlanda  1 , G Vita, C Nicolosi, S Milone, C Messina
Affiliations

Botulinum toxin therapy: distant effects on neuromuscular transmission and autonomic nervous system

P Girlanda et al. J Neurol Neurosurg Psychiatry. 1992 Sep.

Abstract

To evaluate distant effects of botulinum toxin, single fibre electromyography on the extensor digitorum communis muscle and six tests of cardiovascular reflexes were performed in five patients injected with BoTox (Oculinum(R) 20-130 units) for craniocervical dystonia and hemifacial spasm. Patients underwent two sessions of treatment and the second time the dosage was doubled. Botulinum toxin injection induced an increase of mean jitter value above normal limits in all cases. An increase of fibre density was recorded six weeks after the treatment. Cardiovascular reflexes showed mild abnormalities in four patients. The data confirm distant effects of botulinum toxin on neuromuscular transmission and on autonomic function.

PubMed Disclaimer

References

    1. Naunyn Schmiedebergs Arch Pharmacol. 1976;292(2):161-5 - PubMed
    1. J Neurol. 1991 Aug;238(5):251-5 - PubMed
    1. Eur Neurol. 1990;30(3):142-4 - PubMed
    1. Neuroscience. 1982 Apr;7(4):997-1006 - PubMed
    1. Arch Neurol. 1987 Feb;44(2):202-6 - PubMed

MeSH terms

Substances

LinkOut - more resources