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. 1992 Nov;12(11):5217-27.
doi: 10.1128/mcb.12.11.5217-5227.1992.

Characterization of a new tissue-specific transcription factor binding to the simian virus 40 enhancer TC-II (NF-kappa B) element

A L Lattion  1 , E Espel, P Reichenbach, C Fromental, P Bucher, A Israël, P Baeuerle, N R Rice, M Nabholz
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Characterization of a new tissue-specific transcription factor binding to the simian virus 40 enhancer TC-II (NF-kappa B) element

A L Lattion et al. Mol Cell Biol. 1992 Nov.

Abstract

We have biochemically and functionally characterized a new transcription factor, NP-TCII, which is present in nuclei from unstimulated T and B lymphocytes but is not found in nonhematopoietic cells. This factor has a DNA-binding specificity similar to that of NF-kappa B but is unrelated to this or other Rel proteins by functional and biochemical criteria. It can also be distinguished from other previously described lymphocyte-specific DNA-binding proteins.

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