Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Oct 15;359(6396):609-14.
doi: 10.1038/359609a0.

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

A Hemmati-Brivanlou  1 , D A Melton
Affiliations

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

A Hemmati-Brivanlou et al. Nature. .

Abstract

Activins can induce mesoderm in embryonic explants and have been proposed as the natural inducer in Xenopus. A mutant activin receptor that inhibits activin signalling is used to show that activin is required for the induction of mesoderm in vivo and the patterning of the embryonic body plan. Blocking the activin signal transduction pathway also reveals autonomous induction of a neural marker and unmasks a relationship between activin and fibroblast growth factor.

PubMed Disclaimer

Comment in

LinkOut - more resources