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Comparative Study
. 1976 May-Jun;19(3):532-8.
doi: 10.1002/art.1780190304.

Mixed leukocyte reaction in rheumatoid arthritis

E C Keystone, D D Gladman, M B Urowitz, D A Clarke, J A Falk, D Osoba, D A Gordon
Comparative Study

Mixed leukocyte reaction in rheumatoid arthritis

E C Keystone et al. Arthritis Rheum. 1976 May-Jun.

Abstract

The mixed leukocyte reaction (MLR) responses of 29 patients with classic rheumatoid arthritis (RA) were compared with those of 24 age- and sex-matched healthy controls. Pools of stimulating cells were selected to include the major cross-reacting HL-A specificities. In pooled human serum the MLR response of the RA lymphocytes was significantly enhanced relative to the response controls (P less than 0.05). In autologous serum there was suppression of the MLR response in patients with RA which correlated with disease activity. The data suggest the presence of an intrinsically enhanced cellular reactivity of RA lymphocytes suppressed by serologic factor(s). The mechanisms of this enhancement of suppression are discussed.

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