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. 1956 Mar 1;103(3):295-9.
doi: 10.1084/jem.103.3.295.

The preparation and function of the hypertensin-converting enzyme

L T SKEGGS Jr, J R KAHN, N P SHUMWAY

The preparation and function of the hypertensin-converting enzyme

L T SKEGGS Jr et al. J Exp Med. .

Abstract

It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the pressor activity of hypertensin I results from its rapid conversion to hypertensin II. An enzyme which effects this conversion has been procured from horse plasma in a semipurified form by means of ammonium sulfate fractionation and isoelectric precipitation. A method is described for estimating the activity of the enzyme. An example of the use of the preparation in converting purified hypertensin I to hypertensin II has been described.

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