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. 1992 Oct;107(2):273-5.
doi: 10.1111/j.1476-5381.1992.tb12737.x.

Non-specific activity of (+/-)-CP-96,345 in models of pain and inflammation

A Nagahisa  1 , R Asai, Y Kanai, A Murase, M Tsuchiya-Nakagaki, T Nakagaki, T C Shieh, K Taniguchi
Affiliations

Non-specific activity of (+/-)-CP-96,345 in models of pain and inflammation

A Nagahisa et al. Br J Pharmacol. 1992 Oct.

Abstract

The non-peptide NK1 receptor antagonist, CP-96,345, and its 2R,3R enantiomer CP-96,344, which is not an NK1 receptor antagonist (IC50 > 10 microM), were evaluated for antinociceptive and anti-inflammatory activities in several classical models of pain and inflammation in the rat. Both CP-96,345 and CP-96,344 reduced carrageenin-induced paw oedema and hyperalgesia, and attenuated the second phase of formalin-induced paw licking with equal potency. These results indicate that NK1 antagonism is not responsible for the activity of (+/-)-CP-96,345 in the above animal models.

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