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. 1992 Jun 17;216(3):449-51.
doi: 10.1016/0014-2999(92)90445-a.

Supersensitivity to morphine of the transmurally stimulated vas deferens isolated from ethanol-pretreated mice

R Tabach  1 , S De Moraes
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Supersensitivity to morphine of the transmurally stimulated vas deferens isolated from ethanol-pretreated mice

R Tabach et al. Eur J Pharmacol. .

Abstract

The effect of chronic ethanol pretreatment on the sensitivity of the transmurally stimulated mouse vas deferens to morphine was studied. Vasa deferentia isolated from ethanol-pretreated mice showed supersensitivity to the twitch inhibitory effect of morphine. The affinity of the vas deferens mu-opioid receptors for naloxone was increased. It is concluded that ethanol pretreatment induces mu-opioid receptor alterations which are, at least partially, responsible for the observed supersensitivity to morphine.

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