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. 1977 Jan;296(2):139-42.
doi: 10.1007/BF00508465.

Analysis of the actions of cimetidine and metiamide on gastric acid secretion in the isolated guinea pig gastric mucosa

S E Sjöstrand, B Ryberg, L Olbe

Analysis of the actions of cimetidine and metiamide on gastric acid secretion in the isolated guinea pig gastric mucosa

S E Sjöstrand et al. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jan.

Abstract

Cumulative dose-response curves for histamine were determined on acid secretion from the isolated guinea pig gastric mucosa. Two H2-receptor antagonists-metiamide and cimetidine-behaved like competitive antagonists to histamine on gastric acid secretion in vitro. The isolated guinea pig gastric mucosa seems to be a suitable in vitro model for analysing the action of compounds on receptors involved in acid secretion.

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References

    1. J Physiol. 1975 May;247(1):35P-36P - PubMed
    1. Agents Actions. 1973 Oct;3(3):133-7 - PubMed
    1. Eur J Pharmacol. 1974 Nov;29(1):83-8 - PubMed