Comparative Study
doi: 10.1002/prot.340140307.
Structural studies of the retroviral proteinase from avian myeloblastosis associated virus
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- PMID: 1332025
- DOI: 10.1002/prot.340140307
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Comparative Study
Structural studies of the retroviral proteinase from avian myeloblastosis associated virus
Proteins.
1992 Nov.
Abstract
The structure of the retroviral proteinase from avian myeloblastosis associated virus (MAV) has been determined and refined at 2.2 A resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type 1 virus (HIV). Through comparison with the structure of a proteinase-inhibitor complex from HIV, a model of a complex between MAV proteinase and a peptide substrate has been generated. Examination of this model suggests structural basis for the diverse specifications of viral proteinases.
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