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Comparative Study
. 1992 Nov;14(3):382-91.
doi: 10.1002/prot.340140307.

Structural studies of the retroviral proteinase from avian myeloblastosis associated virus

D H Ohlendorf  1 , S I Foundling, J J Wendoloski, J Sedlacek, P Strop, F R Salemme
Affiliations
Comparative Study

Structural studies of the retroviral proteinase from avian myeloblastosis associated virus

D H Ohlendorf et al. Proteins. 1992 Nov.

Abstract

The structure of the retroviral proteinase from avian myeloblastosis associated virus (MAV) has been determined and refined at 2.2 A resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type 1 virus (HIV). Through comparison with the structure of a proteinase-inhibitor complex from HIV, a model of a complex between MAV proteinase and a peptide substrate has been generated. Examination of this model suggests structural basis for the diverse specifications of viral proteinases.

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