The effect of lidocaine on oxygen free radical production by polymorphonuclear neutrophils
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- PMID: 1332451
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The effect of lidocaine on oxygen free radical production by polymorphonuclear neutrophils
Agents Actions.
1992.
Abstract
During myocardial ischemia and subsequent reperfusion, activation of polymorphonuclear neutrophils occurs and results in an increased production of oxygen free radicals that participate in the generation of reperfusion arrhythmias. We investigated the effect of antiarrhythmic drug lidocaine on oxygen free radicals production by activated neutrophils in vitro with a chemiluminescence assay. Lidocaine reduced lucigenin-amplified chemiluminescence related to the superoxide anion production but failed to affect hydrogen-peroxide dependent luminol chemiluminescence.
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