Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1956 Jul 1;104(1):151-7.
doi: 10.1084/jem.104.1.151.

Analytical pathology. IV. The role of localized antibodies in the pathogenesis of nephrotoxic nephritis in the rat

L G ORTEGA, R C MELLORS

Analytical pathology. IV. The role of localized antibodies in the pathogenesis of nephrotoxic nephritis in the rat

L G ORTEGA et al. J Exp Med. .

Abstract

The principal objective of this investigation was to define the roles of injected and autogenous, kidney-localizing antibodies in the pathogenesis of rat nephrotoxic nephritis by relating data obtained with fluorescent antibody techniques to clinical and histologic observations. Such an analysis of the nephritis that developed in 28 rats after injection with the crude gamma-globulin fraction of nephrotoxic serum has led us to the following conclusions:- The renal localization of nephrotoxic antibodies is primarily and, perhaps, exclusively in the membranes of the glomerular tufts. These antibodies are demonstrable, as antigens, in the glomeruli for up to 3 months after injection. In the acute stage of the nephritis, non-antibody, autogenous globulins are present in the glomerular tufts, probably as components of edema fluid. From 6 and 9 days to 3 months after injection, autogenous antibodies are localized in the glomerular tufts in a pattern that corresponds closely to that of the nephrotoxins. The essential requirements for the operation of the mechanism postulated by Kay are fulfilled in rat nephrotoxic nephritis.

PubMed Disclaimer

References

    1. Am J Pathol. 1952 Sep-Oct;28(5):863-73 - PubMed
    1. AMA Arch Pathol. 1952 Nov;54(5):463-503 - PubMed
    1. Methods Med Res. 1952;5:284-300 - PubMed
    1. Br J Exp Pathol. 1953 Feb;34(1):27-34 - PubMed
    1. Am J Pathol. 1954 Mar-Apr;30(2):311-35 - PubMed