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. 1992 Sep;10(5):309-14.
doi: 10.1002/stem.5530100509.

Molecular cloning of the cDNA encoding a receptor tyrosine kinase-related molecule with a catalytic region homologous to c-met

S R Paul  1 , D Merberg, H Finnerty, G E Morris, J C Morris, S S Jones, R Kriz, K J Turner, C R Wood
Affiliations

Molecular cloning of the cDNA encoding a receptor tyrosine kinase-related molecule with a catalytic region homologous to c-met

S R Paul et al. Int J Cell Cloning. 1992 Sep.

Abstract

Receptor tyrosine kinases mediate a range of growth and differentiation processes in multiple biological systems. In this work, we report the identification of a novel tyrosine kinase-related molecule, nyk-r, and the molecular cloning of its complete cDNA. Its extra-cellular domain bears no apparent homology with other receptor families, but its intracellular kinase-related region has considerable similarity with members of the insulin-receptor family such as c-met and trk B. Also, the nyk-r gene is expressed in a wide range of tissues and cell lines.

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