Effects of foetal treatment with methylazoxymethanol on noradrenergic synapses in rat cerebral cortex
- PMID: 1333598
- DOI: 10.1111/j.1600-0773.1992.tb00991.x
Effects of foetal treatment with methylazoxymethanol on noradrenergic synapses in rat cerebral cortex
Abstract
Methylazoxymethanol (MAM)-induced cerebral hypoplasia resulted in a significant increase in densities of norepinephrine uptake sites in cerebral cortex, suggesting that norepinephrinergic axon terminals were compressed in the smaller brain volumes. The density of beta-adrenergic receptors in MAM-lesioned cerebral cortex was decreased probably due to down-regulation, while there were no changes in the proportions and affinities of agonist high-affinity sites and agonist low-affinity sites in the desensitized beta-receptors.
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