Effects of angiotensin peptides on cholinergic neurotransmission in rabbit tracheal smooth muscle
- PMID: 1333626
Effects of angiotensin peptides on cholinergic neurotransmission in rabbit tracheal smooth muscle
Abstract
To determine the effects of angiotensins I, II, and III (A I, A II, and A III) on airway smooth muscle functions, we studied isolated tracheal segments from rabbits under isometric conditions in vitro. Addition of A II and A III but not A I potentiated the contractile response to electrical field stimulation (EFS) at 5 Hz in a dose-dependent fashion. The frequency-response curves for EFS were displaced to the left by A II and A III, whereas the contractile responses to exogenous acetylcholine remained unchanged. Angiotensin-induced potentiation of the response to EFS was further increased in the presence of physostigmine. These results suggest that A II and A III may prejunctionally potentiate the vagally-mediated contraction of airway smooth muscle.
Similar articles
-
Corticotropin-releasing factor potentiates the contractile response of rabbit airway smooth muscle to electrical field stimulation but not to acetylcholine.Am Rev Respir Dis. 1989 Nov;140(5):1331-5. doi: 10.1164/ajrccm/140.5.1331. Am Rev Respir Dis. 1989. PMID: 2817596
-
Chemical oxidant potentiates electrically and acetylcholine-induced contraction in rat trachea: possible involvement of cholinesterase inhibition.J Pharmacol Exp Ther. 1991 Oct;259(1):371-6. J Pharmacol Exp Ther. 1991. PMID: 1920123
-
Influence of endothelin-1 on cholinergic nerve-mediated contractions and acetylcholine release in rat isolated tracheal smooth muscle.J Pharmacol Exp Ther. 1996 Dec;279(3):1142-7. J Pharmacol Exp Ther. 1996. PMID: 8968335
-
Actions of angiotensin on adrenergic nerve endings.Fed Proc. 1978 Feb;37(2):199-202. Fed Proc. 1978. PMID: 23967 Review.
-
Cholinergic inhibition of adrenergic transmission.Fed Proc. 1977 Sep;36(10):2444-9. Fed Proc. 1977. PMID: 196943 Review. No abstract available.
Cited by
-
Effect of candesartan, a type 1 angiotensin II receptor antagonist, on bronchial hyper-responsiveness to methacholine in patients with bronchial asthma.Br J Clin Pharmacol. 2002 Dec;54(6):622-6. doi: 10.1046/j.1365-2125.2002.t01-4-01689.x. Br J Clin Pharmacol. 2002. PMID: 12492610 Free PMC article. Clinical Trial.
-
Inhibitory effects of atropine and hexamethonium on the angiotensin II-induced contractions of rat anococcygeus smooth muscles.Naunyn Schmiedebergs Arch Pharmacol. 2003 Feb;367(2):176-82. doi: 10.1007/s00210-002-0659-2. Epub 2003 Jan 16. Naunyn Schmiedebergs Arch Pharmacol. 2003. PMID: 12595959