[The effect of ftorotan on the lipid and cAMP content of the liver in hypoxia]

Abstract

A study was made of the content of cAMP, triglycerides and nonesterified fatty acids in the liver of rats anesthesized with halothane under conditions of spontaneous respiration depending on the oxygen content in the inhalation mixture. As the content of oxygen in the inhalation mixture was reduced, the content of cAMP in the liver was decreased, the intensity of lipolysis was disturbed with subsequent derangement of fatty acids oxidation. The raising of the oxygen content in the inhalation mixture did not disturb the activity of the adenylate cyclase system or provoked deep lipolysis disorders in the liver.