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. 1992 Dec 21;314(3):315-21.
doi: 10.1016/0014-5793(92)81496-9.

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau

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Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau

E M Mandelkow et al. FEBS Lett. .
Free article

Abstract

The Alzheimer-like state of tau protein includes phosphorylation by a proline-directed Ser/Thr kinase present in normal or pathological human brain. Extending earlier results on MAP kinase, we show here that the proline-directed kinase, GSK3, can induce an Alzheimer-like immune response involving several distinct and phosphorylatable epitopes at Ser-Pro motifs, as well as a gel mobility shift, similar to MAP kinase. Both kinases behave like microtubule-associated proteins in that they co-purify through cycles of assembly and disassembly, and both kinases are directly associated with paired helical filaments.

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