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Comparative Study
. 1992 Nov 27;35(24):4628-33.
doi: 10.1021/jm00102a017.

Antirhinoviral activity of heterocyclic analogs of Win 54954

T R Bailey  1 , G D Diana, P J Kowalczyk, V Akullian, M A Eissenstat, D Cutcliffe, J P Mallamo, P M Carabateas, D C Pevear
Affiliations
Comparative Study

Antirhinoviral activity of heterocyclic analogs of Win 54954

T R Bailey et al. J Med Chem. .

Abstract

A variety of heterocyclic analogs of Win 54954 have been synthesized and tested in vitro against human rhinovirus type 14 (HRV-14) in a plaque reduction assay. The more active compounds were tested against 14 additional serotypes, and the concentration which inhibited 80% of the serotypes tested (MIC80) was measured. One compound, 37, exhibited activity comparable to Win 59454. Physicochemical as well as electrostatic parameters were calculated and the results subjected to a QSAR analysis in an effort to explain differences in activity observed between these compounds; however, no meaningful correlation with biological activity was found with any of these parameters.

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