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Comparative Study
. 1992 Dec 5;228(3):1003-10.
doi: 10.1016/0022-2836(92)90887-p.

African swine fever virus encodes a gene with extensive homology to type II DNA topoisomerases

S A Baylis  1 , L K Dixon, S Vydelingum, G L Smith
Affiliations
Comparative Study

African swine fever virus encodes a gene with extensive homology to type II DNA topoisomerases

S A Baylis et al. J Mol Biol. .

Abstract

Nucleotide sequencing of a virulent African swine fever virus (ASFV) isolate (Malawi LIL20/1) identified an open reading frame of 1191 amino acid residues encoding a protein of 134.9 kDa. This gene mapped to the SalI i and j restriction endonuclease fragments of the ASFV genome. The predicted polypeptide was found to share 21.1% identity over a 1077 amino acid region with the human type II DNA topoisomerase. The sequence is compared to other type II DNA topoisomerases and the possible roles in ASFV replication are discussed.

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