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Comparative Study
. 1992 Dec 18;258(5090):1952-5.
doi: 10.1126/science.1335167.

Cloning of a delta opioid receptor by functional expression

C J Evans  1 , D E Keith Jr, H Morrison, K Magendzo, R H Edwards
Affiliations
Comparative Study

Cloning of a delta opioid receptor by functional expression

C J Evans et al. Science. .

Abstract

Opiate drugs have potent analgesic and addictive properties. These drugs interact with receptors that also mediate the response to endogenous opioid peptide ligands. However, the receptors for opioids have eluded definitive molecular characterization. By transient expression in COS cells and screening with an iodinated analog of the opioid peptide enkephalin, a complementary DNA clone encoding a functional delta opioid receptor has been identified. The sequence shows homology to G protein-coupled receptors, in particular the receptors for somatostatin, angiotensin, and interleukin-8.

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