Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Nov;74(11):1019-23.
doi: 10.1016/0300-9084(92)90022-7.

Does cruciform DNA provide a recognition signal for DNA-topoisomerase II?

F Pognan  1 , C Paoletti
Affiliations

Does cruciform DNA provide a recognition signal for DNA-topoisomerase II?

F Pognan et al. Biochimie. 1992 Nov.

Abstract

Topoisomerase II displays higher affinity for supercoiled DNA compared to the same relaxed DNA. Moreover, cruciform structures are formed in topologically constrained DNA. Here we report that, using S1 nuclease experiments on supercoiled DNA, hairpin structures are located close to numerous topoisomerase II cleavage sites on the BPV I genome. Therefore, DNA secondary structure may play a role in the recognition mechanism of DNA by topoisomerase II.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources