Review
doi: 10.1016/s0959-437x(05)80110-8.
Transcriptional regulation and transpositional selection of active SINE sequences
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- PMID: 1335809
- DOI: 10.1016/s0959-437x(05)80110-8
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Review
Transcriptional regulation and transpositional selection of active SINE sequences
Curr Opin Genet Dev.
1992 Dec.
Abstract
Alu repeats are short interspersed elements whose transposition has lead to genetic variability and heritable disorders in humans. A select subset of the nearly one million Alu sequences in human DNA actually produce new transpositions. The evolution of newly inserted Alu repeats is currently a key subject for study. Mechanisms of RNA polymerase III activity and the sequence environment into which an Alu inserts might select for transcriptional and posttranscriptional determinants of Alu transposition.
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