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. 1992 Nov 13;223(1):103-4.
doi: 10.1016/0014-2999(92)90824-n.

Nitric oxide donors increase mucus gel thickness in rat stomach

J F Brown  1 , P J Hanson, B J Whittle
Affiliations

Nitric oxide donors increase mucus gel thickness in rat stomach

J F Brown et al. Eur J Pharmacol. .

Abstract

Instillation of the nitric oxide (NO) generator isosorbide dinitrate (0.1-1 mM) into the rat gastric lumen in vivo produced a dose-related increase in mucus gel thickness that was prevented by coadministration of oxyhaemoglobin (10 microM). Isosorbide dinitrate did not induce epithelial cell damage. S-Nitroso-N-acetyl-penicillamine (0.3 mM) and dibutyryl cyclic GMP (1 mM) also increased mucus thickness. These findings, along with the presence of NO synthase in the gastric mucosa, imply a role for NO in vivo in mediation of gastric mucus release.

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