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Review
. 1992 Dec 1;228(4):179-99.
doi: 10.1016/0926-6917(92)90029-c.

Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept

U G Ahlborg  1 , A Brouwer, M A Fingerhut, J L Jacobson, S W Jacobson, S W Kennedy, A A Kettrup, J H Koeman, H Poiger, C Rappe, et al.
Affiliations
Review

Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept

U G Ahlborg et al. Eur J Pharmacol. .

Abstract

A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.

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