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Comparative Study
. 1992 Sep-Oct;42(5):993-7.

[The influence of epiphysectomy and melatonin on the antidepressive effect in disordered function of the beta-adrenergic mechanisms in rats]

[Article in Russian]
E B Arushanian, E V Beĭer
  • PMID: 1336286
Comparative Study

[The influence of epiphysectomy and melatonin on the antidepressive effect in disordered function of the beta-adrenergic mechanisms in rats]

[Article in Russian]
E B Arushanian et al. Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 Sep-Oct.

Abstract

After chronic administration of beta-adrenoblocker propranolol (1 mg/kg, 14 days) reorganization of time course of forced swimming with decrease of rhythmical index of depression was observed. Pinealectomy slightly attenuated, and melatonin (1 mg/kg) potentiated this effect. As proposed, antidepressive properties of beta-adrenoblockade primarily are not connected with pharmacological denervation of the pineal gland.

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