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Comparative Study
. 1992 Nov;83(11):1179-83.
doi: 10.1111/j.1349-7006.1992.tb02742.x.

Phenotypic properties of liver tumors induced by dehydroepiandrosterone in F-344 rats

M S Rao  1 , V Subbarao, S Kumar, A V Yeldandi, J K Reddy
Affiliations
Comparative Study

Phenotypic properties of liver tumors induced by dehydroepiandrosterone in F-344 rats

M S Rao et al. Jpn J Cancer Res. 1992 Nov.

Abstract

Dehydroepiandrosterone (DHEA), a C19 adrenal steroid hormone, induces peroxisome proliferation in liver cells and is hepatocarcinogenic in the rat. The present study deals with the phenotypic properties of DHEA-induced liver lesions. A majority of the altered areas (80-87%), neoplastic nodules (> 94%) and hepatocellular carcinomas (HCC, 80-100%) lacked the marker enzymes gamma-glutamyltranspeptidase and placental form of glutathione S-transferase (GSTP). Northern blot analysis of HCC from 4 rats revealed no detectable GSTP mRNA. These HCC, however, showed a marked decrease in the staining of glucose-6-phosphatase and adenosine triphosphatase. These results indicate that the phenotypic properties of liver tumors induced by DHEA and amphipathic carboxylate peroxisome proliferators are similar.

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