doi: 10.1055/s-2006-961535.
Anti-inflammatory activity of gallic acid
Affiliations
- PMID: 1336604
- DOI: 10.1055/s-2006-961535
Item in Clipboard
Anti-inflammatory activity of gallic acid
Planta Med.
1992 Dec.
Abstract
Gallic acid was found to possess antiinflammatory activity towards zymosan-induced acute food pad swelling in mice. In vitro studies on the mode of action of gallic acid revealed that this compound interferes with the functioning of polymorphonuclear leukocytes (PMNs). Scavenging of superoxide anions, inhibition of myeloperoxidase release and activity as well as a possible interference with the assembly of active NADPH-oxidase may account for the inhibition of inflammatory process by gallic acid. Structure-activity relationship analysis showed that the o-dihydroxy group of gallic acid is important for the inhibitory activity in vitro.
Similar articles
-
Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives.Neurochem Int. 2006 Mar;48(4):263-74. doi: 10.1016/j.neuint.2005.10.010. Epub 2005 Dec 15. Neurochem Int. 2006. PMID: 16343693
-
Anti-inflammatory activity of extracts from leaves of Phyllanthus emblica.Planta Med. 1997 Dec;63(6):518-24. doi: 10.1055/s-2006-957754. Planta Med. 1997. PMID: 9434603
-
Activation of equine neutrophils by phorbol myristate acetate or N-formyl-methionyl-leucyl-phenylalanine induces a different response in reactive oxygen species production and release of active myeloperoxidase.Vet Immunol Immunopathol. 2009 Aug 15;130(3-4):243-50. doi: 10.1016/j.vetimm.2009.02.015. Epub 2009 Mar 4. Vet Immunol Immunopathol. 2009. PMID: 19328559
-
Bioactivity of flavonoids.Pol J Pharmacol. 1996 Nov-Dec;48(6):555-64. Pol J Pharmacol. 1996. PMID: 9112694 Review.
-
Medicinal importance of gallic acid and its ester derivatives: a patent review.Pharm Pat Anal. 2015;4(4):305-15. doi: 10.4155/ppa.15.14. Pharm Pat Anal. 2015. PMID: 26174568 Review.
Cited by
-
Anti-Inflammatory Effects of Water Chestnut Extract on Cytokine Responses via Nuclear Factor-κB-signaling Pathway.Biomol Ther (Seoul). 2015 Jan;23(1):90-7. doi: 10.4062/biomolther.2014.080. Epub 2015 Jan 1. Biomol Ther (Seoul). 2015. PMID: 25593649 Free PMC article.
-
Theoretical study on the radical scavenging activity of gallic acid.Heliyon. 2023 Jan 5;9(1):e12806. doi: 10.1016/j.heliyon.2023.e12806. eCollection 2023 Jan. Heliyon. 2023. PMID: 36691549 Free PMC article.
-
Cistus albidus L.-Review of a Traditional Mediterranean Medicinal Plant with Pharmacological Potential.Plants (Basel). 2023 Aug 18;12(16):2988. doi: 10.3390/plants12162988. Plants (Basel). 2023. PMID: 37631199 Free PMC article. Review.
-
Effect of JJYMD-C, a novel synthetic derivative of gallic acid, on proliferation and phenotype maintenance in rabbit articular chondrocytes in vitro.Braz J Med Biol Res. 2014 Aug;47(8):637-45. doi: 10.1590/1414-431x20143935. Epub 2014 Jul 8. Braz J Med Biol Res. 2014. PMID: 25003544 Free PMC article.
-
Non-Nutrient, Naturally Occurring Phenolic Compounds with Antioxidant Activity for the Prevention and Treatment of Periodontal Diseases.Antioxidants (Basel). 2015 Jun 24;4(3):447-81. doi: 10.3390/antiox4030447. Antioxidants (Basel). 2015. PMID: 26783837 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
