Noradrenergic innervation of the human adrenal cortex as revealed by dopamine-beta-hydroxylase immunohistochemistry
Affiliations
- PMID: 1336772
- PMCID: PMC1259650
Item in Clipboard
Noradrenergic innervation of the human adrenal cortex as revealed by dopamine-beta-hydroxylase immunohistochemistry
J Anat.
1992 Jun.
Abstract
Noradrenergic innervation of the human adrenal cortex was investigated using immunohistochemistry directed at dopamine-beta-hydroxylase. Nerves were present as slender trunks and individual varicose fibres in the capsule and all cortical zones except the inner zona reticularis. Some fibres were located adjacent to blood vessels and in the muscular tunics of arterioles; others were apparently adjacent to parenchymal cells. These results in the human confirm and extend previous animal studies and suggest a possible anatomical substrate for regulation of adrenal blood flow, and also for the direct action of noradrenaline on zona fasciculata cells to stimulate glucocorticoid secretion via beta-1-adrenoceptors.
Similar articles
-
Innervation of the human adrenal cortex: simultaneous visualisation using acetylcholinesterase histochemistry and dopamine beta-hydroxylase immunohistochemistry.Acta Anat (Basel). 1993;146(1):31-5. doi: 10.1159/000147417. Acta Anat (Basel). 1993. PMID: 8434504
-
A preliminary study of acetylcholinesterase-positive innervation in the human adrenal cortex.J Anat. 1991 Jun;176:99-104. J Anat. 1991. PMID: 1717421 Free PMC article.
-
Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamine-beta-hydroxylase.J Comp Neurol. 1989 Jan 8;279(2):249-71. doi: 10.1002/cne.902790208. J Comp Neurol. 1989. PMID: 2563268
-
Innervation of the adrenal cortex, its physiological relevance, with primary focus on the noradrenergic transmission.Microsc Res Tech. 1997 Mar 15;36(6):534-45. doi: 10.1002/(SICI)1097-0029(19970315)36:6<534::AID-JEMT10>3.0.CO;2-P. Microsc Res Tech. 1997. PMID: 9142699 Review.
-
[The mechanisms of corticoids biosynthesis revealed by immunohistochemistry and in situ hybridization].Kaibogaku Zasshi. 1998 Apr;73(2):111-8. Kaibogaku Zasshi. 1998. PMID: 9617077 Review. Japanese.
Cited by
-
Role of neurotransmitters and neuropeptides in the regulation of the adrenal cortex.Rev Endocr Metab Disord. 2001 Aug;2(3):253-67. doi: 10.1023/a:1011512415497. Rev Endocr Metab Disord. 2001. PMID: 11708293 Review. No abstract available.
-
Post-Mortem Immunohistochemical Evidence of β2-Adrenergic Receptor Expression in the Adrenal Gland.Int J Mol Sci. 2019 Jun 23;20(12):3065. doi: 10.3390/ijms20123065. Int J Mol Sci. 2019. PMID: 31234562 Free PMC article.
-
Elevation of corticosterone and 17OH progesterone in extremely preterm infants and clinical implications.Pediatr Res. 2025 Aug 7. doi: 10.1038/s41390-025-04216-5. Online ahead of print. Pediatr Res. 2025. PMID: 40775060
-
Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice.Sci Rep. 2022 Jul 20;12(1):12365. doi: 10.1038/s41598-022-16487-7. Sci Rep. 2022. PMID: 35858980 Free PMC article.
-
The neuropeptide substance P regulates aldosterone secretion in human adrenals.Nat Commun. 2020 May 29;11(1):2673. doi: 10.1038/s41467-020-16470-8. Nat Commun. 2020. PMID: 32471973 Free PMC article. Clinical Trial.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources