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Comparative Study
. 1992 Dec;55(12):1732-40.
doi: 10.1021/np50090a003.

Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis

M Amoros  1 , C M Simões, L Girre, F Sauvager, M Cormier
Affiliations
Comparative Study

Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis

M Amoros et al. J Nat Prod. 1992 Dec.

Abstract

The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol combinations has been also investigated. The synergy demonstrated by all combinations could explain why propolis is more active than its individual compounds.

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