Review
doi: 10.1093/hmg/1.5.293.
Dominant negative mutations in the Wilms tumour (WT1) gene cause Denys-Drash syndrome--proof that a tumour-suppressor gene plays a crucial role in normal genitourinary development
Affiliations
- PMID: 1338905
- DOI: 10.1093/hmg/1.5.293
Item in Clipboard
Review
Dominant negative mutations in the Wilms tumour (WT1) gene cause Denys-Drash syndrome--proof that a tumour-suppressor gene plays a crucial role in normal genitourinary development
Hum Mol Genet.
1992 Aug.
No abstract available
Similar articles
-
Effects of Denys-Drash syndrome point mutations on the DNA binding activity of the Wilms' tumor suppressor protein WT1.Biochemistry. 1996 Sep 17;35(37):12070-6. doi: 10.1021/bi960758o. Biochemistry. 1996. PMID: 8810912
-
Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome.Cell. 1991 Oct 18;67(2):437-47. doi: 10.1016/0092-8674(91)90194-4. Cell. 1991. PMID: 1655284
-
Constitutional mutations in the WT1 gene in patients with Denys-Drash syndrome.Hum Mol Genet. 1992 Aug;1(5):301-5. doi: 10.1093/hmg/1.5.301. Hum Mol Genet. 1992. PMID: 1338906
-
Atypical presentation of Denys-Drash syndrome in a female with a novel Wt1 gene mutation.Birth Defects Orig Artic Ser. 1996;30(1):269-86. Birth Defects Orig Artic Ser. 1996. PMID: 9125334 Review. No abstract available.
-
The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor.FASEB J. 1993 Jul;7(10):896-903. FASEB J. 1993. PMID: 8393820 Review.
Cited by
-
Colocalization of WT1 and cell proliferation reveals conserved mechanisms in temperature-dependent sex determination.Genesis. 2003 Apr;35(4):193-201. doi: 10.1002/gene.10176. Genesis. 2003. PMID: 12717730 Free PMC article.
-
Microdissecting the genetic events in nephrogenic rests and Wilms' tumor development.Am J Pathol. 1998 Sep;153(3):991-1000. doi: 10.1016/S0002-9440(10)65641-6. Am J Pathol. 1998. PMID: 9736048 Free PMC article.
-
The expanding phenotypic spectra of kidney diseases: insights from genetic studies.Nat Rev Nephrol. 2016 Aug;12(8):472-83. doi: 10.1038/nrneph.2016.87. Epub 2016 Jul 4. Nat Rev Nephrol. 2016. PMID: 27374918 Review.
-
Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination.Am J Hum Genet. 2010 Dec 10;87(6):898-904. doi: 10.1016/j.ajhg.2010.11.003. Am J Hum Genet. 2010. PMID: 21129722 Free PMC article.
-
The new dysmorphology: application of insights from basic developmental biology to the understanding of human birth defects.Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8566-73. doi: 10.1073/pnas.92.19.8566. Proc Natl Acad Sci U S A. 1995. PMID: 7567976 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
