[Flow cytometric analysis of DNA content in lung cancer]

Abstract

DNA index (DI) was studied with flow cytometry in surgical samples from 35 patients with lung cancer, 10 patients with benign lesions, 10 normal persons. The results showed that DI of lung cancer is significantly higher than that of benign pathological lesion and normal lung (P < 0.001). Aneuploid lung cancer was 88.57%, diploid was 11.43%. The DNA content of benign and normal lung was diploid. In the meantime, A significant positive correlation between the lung cancer DI and histopathological grade and cancer cell type was also observed, but there is not correlation between the TNM staging and lung cancer DI. Our results suggest that the flow cytometric analysis of DNA is useful for clinical pathologic diagnosis of lung cancer.