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. 1957 Jun 1;105(6):529-37.
doi: 10.1084/jem.105.6.529.

Bactericidal activity of rat leucocytic extracts. II. Characterization of the bactericidal substance in leucocyte mitochondrial extracts

M FISHMAN, L J COLE, M S SILVERMAN

Bactericidal activity of rat leucocytic extracts. II. Characterization of the bactericidal substance in leucocyte mitochondrial extracts

M FISHMAN et al. J Exp Med. .

Abstract

The bactericidal substance present in mitochondrial extracts from rat leucocytes was found to be non-dialyzable, fractionated at 30 per cent (NH(4)SO(4) saturation and was able to withstand temperatures up to 100 degrees C. The tentative identification of a lipoprotein as the responsible bactericidal substance is based on various observations; an ultraviolet absorption at a peak associated with alpha, beta unsaturated fatty acids, 205 to 208 mmicro, inactivation of the bactericidal substance by ether treatment at -70 degrees C. but not at 0 degrees C. and inhibition of the bactericidal activity with lipase treatment as well as with trypsin.

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References

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