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. 1992 Oct;112(1-2):216-22.
doi: 10.1016/0022-510x(92)90154-d.

Combined effects of a thymic peptide, thymopoietin and myasthenic patient sera in rat myotube culture

B Eymard  1 , C Aimé, C Cottin, E Morel, G Goldstein, J F Bach, S Berrih-Aknin
Affiliations

Combined effects of a thymic peptide, thymopoietin and myasthenic patient sera in rat myotube culture

B Eymard et al. J Neurol Sci. 1992 Oct.

Retraction in

  • Retraction.
    Goldstein G, Aimé C, Berrih-Aknin S, Cottin C, Eymard B, Bach JF, Morel E. Goldstein G, et al. J Neurol Sci. 1993 Dec 1;120(1):120. doi: 10.1016/0022-510x(93)90036-x. J Neurol Sci. 1993. PMID: 8289074 No abstract available.

Abstract

We investigated in a rat myotube assay the combined effect of 26 myasthenic (MG) patient sera and a thymic peptide, thymopoietin (Tpo) which had previously been shown to bind Torpedo and human AChR and to compete with alpha-bungarotoxin (alpha-Bgt) binding. Cultures were first exposed to Tpo alone for 3 h (0.3, 7.5, 15 nM), then MG sera (5% final dilution) were added for an additional 18 h. Reduction in the amount of 125I-alpha-Bgt binding sites in the presence of various concentrations of Tpo were similar with control sera and in all the patients with low or undetectable anti-AChR Ab (11 cases). In cultures exposed to Tpo and sera with high anti-AChR Ab titre (15 cases), Tpo and anti-AChR Ab have an additive capacity to reduce the number of alpha-Bgt binding sites. The results are compatible with the hypothesis that anti-AChR Ab and Tpo could impair neuromuscular transmission by complementary mechanisms.

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