Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Jun 29;364(1):1-6.
doi: 10.1007/BF01062904.

Structural and enzymatic properties of cardiac myosin in ischaemic and non-ischaemic regions of the rat myocardium

Structural and enzymatic properties of cardiac myosin in ischaemic and non-ischaemic regions of the rat myocardium

V Pelouch et al. Pflugers Arch. .

Abstract

In rats with ligation of the left coronary artery changes in ATPase activity and structure of cardiac myosin in both ischaemic and non-ischaemic zones of the myocardium were followed. In control animals, ATPase activity and the structure of the myosin molecule in right and left ventricles did not differ. Non-specific factors, such as anaesthesia and thoracotomy, can result in a decrease or an increase in ATPase activity respectively. One hour after ligation of the left coronary artery ATPase activity increased in the right, non-ischaemic myocardium and there was a significant right-to-left difference. Four hours after ligation, ATPase activity in both ventricles significantly decreased and the right-left difference disappeared. Within 48 h, normal values were found only in the non-ischaemic right ventricle. Ligation of the left coronary artery results after 48 h in the formation of structural alterations in cardiac myosin, primarily in the left, ischaemic myocardium. These changes are characterised by the formation of myosin aggregates, which have a significantly lower ATPase activity in comparison with monomeric myosin.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Biochemistry. 1967 Feb;6(2):528-40 - PubMed
    1. Ann Surg. 1954 Nov;140(5):675-82 - PubMed
    1. J Gen Physiol. 1967 Jul;50(6):Suppl:197-218 - PubMed
    1. Am Heart J. 1968 Nov;76(5):685-98 - PubMed
    1. Biochim Biophys Acta. 1962 Apr 23;58:598-601 - PubMed