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. 1992;18(5):286-9.
doi: 10.1007/BF01706475.

Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis

D J Cooper  1 , K R Walley, P M Dodek, F Rosenberg, J A Russell
Affiliations

Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis

D J Cooper et al. Intensive Care Med. 1992.

Abstract

Plasma ionized calcium [Ca++] concentrations are decreased in patients having lactic acidosis. To further investigate this observation, we prospectively studied nine critically ill patients who had lactic acidosis and measured arterial pH, PCO2, [Ca++], lactate, and albumin concentrations. We found a strong association between decreased [Ca++] and increased plasma lactate concentrations (r2 = 0.78, p less than or equal to 0.001). This unexpected association--[Ca++] usually increases with increasing acidosis--might be clinically important and the mechanism deserves further investigation.

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