Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1957 Jul 1;106(1):15-26.
doi: 10.1084/jem.106.1.15.

A streptococcal enzyme that acts specifically upon diphosphopyridine nucleotide: characterization of the enzyme and its separation from streptolysin O

A S CARLSON, A KELLNER, A W BERNHEIMER, E B FREEMAN

A streptococcal enzyme that acts specifically upon diphosphopyridine nucleotide: characterization of the enzyme and its separation from streptolysin O

A S CARLSON et al. J Exp Med. .

Abstract

All enzyme that destroys DPN has been found in fractionated and highly concentrated streptococcal preparations that also contain streptolysin O. The enzyme-streptococcal DPNase-was shown by electrophoretic separation and by other means to be distinct from streptolysin O. It is non-dialyzable, heat-labile, and has optimal activity in the pH range 7.2 to 7.8. The enzyme has a high degree of specificity for DPN, which it splits at the nicotinamide-ribose linkage.

PubMed Disclaimer

References

    1. J Biol Chem. 1951 Aug;191(2):473-83 - PubMed
    1. J Exp Med. 1956 Oct 1;104(4):577-87 - PubMed
    1. J Exp Med. 1955 May 1;101(5):557-76 - PubMed
    1. J Exp Med. 1957 Jul 1;106(1):27-37 - PubMed
    1. J Biol Chem. 1951 Aug;191(2):447-59 - PubMed