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. 1957 Jun;12(2):228-31.
doi: 10.1111/j.1476-5381.1957.tb00125.x.

Anticonvulsant compounds and 5-hydroxytryptamine in rat brain

D D BONNYCASTLE, N J GIARMAN, M K PAASONEN

Anticonvulsant compounds and 5-hydroxytryptamine in rat brain

D D BONNYCASTLE et al. Br J Pharmacol Chemother. 1957 Jun.

Abstract

In rats, a series of anticonvulsant compounds have been shown to cause a significant elevation of brain 5-hydroxytryptamine (5-HT) levels in comparison with control values. This increase in 5-HT only occurred in brain tissue and was not observed in spleen, upper small intestine or blood. Elevation of brain levels of 5-HT by iproniazid (Marsilid) or 5-hydroxytryptophan failed to give protection against the convulsant or lethal action of lept zol (75 mg./kg.).

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References

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