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. 1957 Sep;12(3):312-9.
doi: 10.1111/j.1476-5381.1957.tb00140.x.

Some actions of substituted choline phenyl ethers, particularly of choline 2:6-xylyl ether

N D EDGE, D F MASON, J H WYLLIE

Some actions of substituted choline phenyl ethers, particularly of choline 2:6-xylyl ether

N D EDGE et al. Br J Pharmacol Chemother. 1957 Sep.

Abstract

Marked nicotine-like stimulant properties are possessed by choline phenyl ether and choline o-tolyl ether, and to a decreasing extent by choline 2:6-xylyl ether and choline 2:4:6-mesityl ether. The compounds all show neuromuscular blocking properties, which are of short duration and pass from mainly decamethonium-like to mainly curare-like as more methyl groups are added to the phenyl nucleus. This series of compounds also possesses muscarinic, weak anti-adrenaline and vasodilator properties, as well as long-lasting local anaesthetic effects in the two compounds tested by intradermal injection.

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References

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    1. Br J Pharmacol Chemother. 1954 Dec;9(4):471-5 - PubMed
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