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. 1957 Sep;12(3):323-8.
doi: 10.1111/j.1476-5381.1957.tb00142.x.

Two kinds of tryptamine receptor

J H GADDUM, Z P PICARELLI

Two kinds of tryptamine receptor

J H GADDUM et al. Br J Pharmacol Chemother. 1957 Sep.

Abstract

There are two kinds of tryptamine receptor in the guinea-pig ileum, namely the M receptors which can be blocked with morphine and the D receptors which can be blocked with dibenzyline. Atropine, an atropine-like drug, cocaine, and methadone inhibit effects due to the M receptors, even after dibenzyline, but have no additional effect after morphine. Lysergic acid diethylamide, dihydroergotamine and 5-benzyloxygramine inhibit effects due to the D receptors, even after morphine, but have no additional effect after dibenzyline. The M receptors are probably in the nervous tissue and the D receptors are probably in the muscles.

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References

    1. J Physiol. 1953 Feb 27;119(2-3):363-8 - PubMed
    1. J Physiol. 1955 Jul 28;129(1):18-9P - PubMed
    1. Br J Pharmacol Chemother. 1953 Dec;8(4):378-88 - PubMed
    1. Br J Pharmacol Chemother. 1955 Dec;10(4):456-61 - PubMed
    1. J Physiol. 1956 Jun 28;132(3):529-41 - PubMed