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. 1957 Sep;12(3):323-8.
doi: 10.1111/j.1476-5381.1957.tb00142.x.

Two kinds of tryptamine receptor

J H GADDUM, Z P PICARELLI

Two kinds of tryptamine receptor

J H GADDUM et al. Br J Pharmacol Chemother. 1957 Sep.

Abstract

There are two kinds of tryptamine receptor in the guinea-pig ileum, namely the M receptors which can be blocked with morphine and the D receptors which can be blocked with dibenzyline. Atropine, an atropine-like drug, cocaine, and methadone inhibit effects due to the M receptors, even after dibenzyline, but have no additional effect after morphine. Lysergic acid diethylamide, dihydroergotamine and 5-benzyloxygramine inhibit effects due to the D receptors, even after morphine, but have no additional effect after dibenzyline. The M receptors are probably in the nervous tissue and the D receptors are probably in the muscles.

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