doi: 10.1111/j.1476-5381.1957.tb00149.x.
The preservation of substance P by lysergic acid diethylamide
- PMID: 13460245
- PMCID: PMC1509706
- DOI: 10.1111/j.1476-5381.1957.tb00149.x
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The preservation of substance P by lysergic acid diethylamide
Br J Pharmacol Chemother.
1957 Sep.
Abstract
Lysergic acid diethylamide (LSD) potentiated the response of guinea-pig ileum to substance P but not to histamine. It also inhibited the disappearance of substance P when incubated with guinea-pig brain extract but not when incubated with chymotrypsin. Eserine, morphine, mescaline, chlorpromazine, ergometrine, strychnine and 2 bromo-LSD did not have this effect. Oxytocin was not destroyed by brain extract. The inhibition of the destruction of substance P by LSD could be antagonized by 2 bromo-LSD. This effect of LSD may have some relation to its pharmacological actions.
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