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. 1992 Jan 1;281 ( Pt 1)(Pt 1):41-3.
doi: 10.1042/bj2810041.

Induction of peroxisomal beta-oxidation genes by retinoic acid in cultured rat hepatocytes

R Hertz  1 , J Bar-Tana
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Induction of peroxisomal beta-oxidation genes by retinoic acid in cultured rat hepatocytes

R Hertz et al. Biochem J. .

Abstract

Retinoic acid is reported here to induce peroxisomal beta-oxidation activities in cultured rat hepatocytes, with a concomitant increase in respective peroxisomal mRNAs. The concentrations of retinoic acid required for inducing liver peroxisomal acyl-CoA oxidase were similar to those required for inducing liver transglutaminase. A putative 5'-flanking response element for retinoic acid may be found within the enhancer region involved in the induction of peroxisomal genes by xenobiotic amphipathic carboxylates.

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