Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Apr;187(2):443-52.
doi: 10.1016/0042-6822(92)90446-v.

Immune response to a murine coronavirus: identification of a homing receptor-negative CD4+ T cell subset that responds to viral glycoproteins

J Mobley  1 , G Evans, M O Dailey, S Perlman
Affiliations

Immune response to a murine coronavirus: identification of a homing receptor-negative CD4+ T cell subset that responds to viral glycoproteins

J Mobley et al. Virology. 1992 Apr.

Abstract

The lymphocyte proliferative response to mouse hepatitis virus, strain JHM (MHV-JHM), a well-described cause of chronic and acute neurological infections, has been studied using vaccinia virus recombinants expressing individual MHV proteins. The surface (S) and transmembrane (M) glycoproteins were the most active proteins in causing proliferation of lymphocytes isolated from immunized adult mice, whereas lymphocytes from persistently infected mice proliferated only in response to the S protein. The cells from immunized mice which proliferated most actively in response to MHV were positive for the CD4 antigen and secreted interferon-gamma. In addition, the most responsive subset of cells did not express gp90MEL-14, the lymph node-specific homing receptor. The results identify a subpopulation of CD4+ T cells that may be an important component of the cell-mediated immune response to this virus. The data also suggest that response to the M protein is important in preventing disease progression in C57BL/6 mice since cells which recognize this protein are absent from persistently infected mice.

PubMed Disclaimer

References

    1. Bradley L., Duncan D., Tonkonogy S., Swain S. Characterization of antigen-specific CD4+ effector T cells in vivo: Immunization results in a transient population of MEL14− CD45RBhelper cells that secrete interleukin 2 (IL-2), IL-3, IL-4 and interferon gamma. J. Exp. Med. 1991;174:547–559. - PMC - PubMed
    1. Buchmeier M.J., Lewicki H.A., Talbot P.J., Knobler R.L. Murine hepatitis virus-4 (strain JHM)-induced neurological disease is modulated in vivo by monoclonal antibody. Virology. 1984;132:261–270. - PMC - PubMed
    1. Carman P.S., Ernst P.E., Rosenthal K.L., Clark D.A., Befus A.D., Biensenstock J. Intraepithelial leukocytes contain a unique subpopulation of NK-like cytotoxic cells active in the defense of epithelium to enteric murine coronavirus. J. Immunol. 1986;136:1548–1553. - PubMed
    1. Cheever F.S., Daniels J.B., Pappenheimer A.M., Bailey O.T. A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin. J. Exp. Med. 1949;90:181–194. - PMC - PubMed
    1. Dailey M.O., Gallatin W.M., Weissman I.L. The in vivo behavior of T cell clones: Altered migration due to loss of the lymphocyte surface homing receptor. J. Mol. Cell. Immunol. 1985;2:27–35. - PubMed

Publication types

MeSH terms